diff --git a/CMakeLists.txt b/CMakeLists.txt
index 703d92f3bbe..0711fe9e6e1 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -16,6 +16,8 @@ if(POLICY CMP0065)
     cmake_policy(SET CMP0065 NEW)
 endif()
 
+include(CMakeDependentOption)
+
 project(REACTOS)
 
 # Versioning
diff --git a/sdk/cmake/config-amd64.cmake b/sdk/cmake/config-amd64.cmake
index 058d4518acb..46a9293d2eb 100644
--- a/sdk/cmake/config-amd64.cmake
+++ b/sdk/cmake/config-amd64.cmake
@@ -44,5 +44,7 @@ set(USERMODE TRUE CACHE BOOL
 if(MSVC)
 set(_PREFAST_ FALSE CACHE BOOL
 "Whether to enable PREFAST while compiling.")
-    option(RUNTIME_CHECKS "Whether to enable runtime checks on MSVC" ON)
+    # RTC are incompatible with compiler optimizations.
+    cmake_dependent_option(RUNTIME_CHECKS "Whether to enable runtime checks on MSVC" ON
+                           "CMAKE_BUILD_TYPE STREQUAL \"Debug\"" OFF)
 endif()
diff --git a/sdk/cmake/config-arm.cmake b/sdk/cmake/config-arm.cmake
index b9f2e2028f9..3290d76a166 100644
--- a/sdk/cmake/config-arm.cmake
+++ b/sdk/cmake/config-arm.cmake
@@ -45,5 +45,7 @@ set(NEWSPRINTF FALSE CACHE BOOL
 "Whether to compile the new sprintf.")
 
 if(MSVC)
-    option(RUNTIME_CHECKS "Whether to enable runtime checks on MSVC" ON)
+    # RTC are incompatible with compiler optimizations.
+    cmake_dependent_option(RUNTIME_CHECKS "Whether to enable runtime checks on MSVC" ON
+                           "CMAKE_BUILD_TYPE STREQUAL \"Debug\"" OFF)
 endif()
diff --git a/sdk/cmake/config.cmake b/sdk/cmake/config.cmake
index d9897426bd8..01c1ac760db 100644
--- a/sdk/cmake/config.cmake
+++ b/sdk/cmake/config.cmake
@@ -83,8 +83,9 @@ set(_PREFAST_ FALSE CACHE BOOL
 "Whether to enable PREFAST while compiling.")
 set(_VS_ANALYZE_ FALSE CACHE BOOL
 "Whether to enable static analysis while compiling.")
-
-    option(RUNTIME_CHECKS "Whether to enable runtime checks on MSVC" ON)
+    # RTC are incompatible with compiler optimizations.
+    cmake_dependent_option(RUNTIME_CHECKS "Whether to enable runtime checks on MSVC" ON
+                           "CMAKE_BUILD_TYPE STREQUAL \"Debug\"" OFF)
 endif()
 
 if(GCC)