diff --git a/reactos/ntoskrnl/config/ntapi.c b/reactos/ntoskrnl/config/ntapi.c
index 7a10d14bfc3..b47f77ffd49 100644
--- a/reactos/ntoskrnl/config/ntapi.c
+++ b/reactos/ntoskrnl/config/ntapi.c
@@ -39,6 +39,9 @@ NtCreateKey(OUT PHANDLE KeyHandle,
             ObjectAttributes->ObjectName, ObjectAttributes->RootDirectory,
             DesiredAccess, CreateOptions);
 
+    /* Ignore the WOW64 flag, it's not valid in the kernel */
+    DesiredAccess &= ~KEY_WOW64_RES;
+
     /* Check for user-mode caller */
     if (PreviousMode != KernelMode)
     {
@@ -126,6 +129,9 @@ NtOpenKey(OUT PHANDLE KeyHandle,
     DPRINT("NtOpenKey(Path: %wZ, Root %x, Access: %x)\n",
             ObjectAttributes->ObjectName, ObjectAttributes->RootDirectory, DesiredAccess);
 
+    /* Ignore the WOW64 flag, it's not valid in the kernel */
+    DesiredAccess &= ~KEY_WOW64_RES;
+
     /* Check for user-mode caller */
     if (PreviousMode != KernelMode)
     {